Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1463)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0783504	0.0998210	0.4412722
Weighted median	23	0.0017897	0.0557461	0.9743893
Inverse variance weighted	23	0.0224474	0.0390159	0.5650617
Simple mode	23	0.0029630	0.0971753	0.9759501
Weighted mode	23	-0.0172474	0.0657869	0.7956296

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.16498	21	0.9594768
Inverse variance weighted	12.36851	22	0.9492944

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00619	0.0056424	0.285038

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003849	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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