Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1462)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0741291	0.0998207	0.4659364
Weighted median	23	0.0535229	0.0561425	0.3404175
Inverse variance weighted	23	0.0622737	0.0390157	0.1104620
Simple mode	23	0.0881190	0.0837498	0.3041419
Weighted mode	23	0.0485405	0.0650229	0.4632603

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.89182	21	0.9123659
Inverse variance weighted	12.90847	22	0.9356825

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000728	0.0056423	0.8985602

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004684	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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