Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1461)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0557139	0.0998203	0.5826494
Weighted median	23	-0.0382066	0.0561289	0.4960659
Inverse variance weighted	23	-0.0448109	0.0390155	0.2507453
Simple mode	23	-0.1128789	0.0980971	0.2622156
Weighted mode	23	-0.0215008	0.0699544	0.7614646

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.57057	21	0.7932733
Inverse variance weighted	16.76760	22	0.7760543

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061732	0.0056423	0.2863057

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005481	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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