Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1460)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0758385	0.1182836	0.5283558
Weighted median	23	0.0058619	0.0627339	0.9255538
Inverse variance weighted	23	0.0215565	0.0460215	0.6394989
Simple mode	23	-0.0606382	0.1022244	0.5591051
Weighted mode	23	-0.0568502	0.0694780	0.4219908

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.48747	21	0.1027815
Inverse variance weighted	30.61114	22	0.1043513

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005981	0.006686	0.3811594

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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