Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 146)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0464831	0.1137832	0.6870249
Weighted median	23	-0.0168681	0.0609443	0.7819503
Inverse variance weighted	23	-0.0611858	0.0445307	0.1694379
Simple mode	23	-0.0590262	0.1184009	0.6230595
Weighted mode	23	-0.0244582	0.0735216	0.7425349

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.28613	21	0.1615819
Inverse variance weighted	28.65937	22	0.1548453

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0066119	0.0064315	0.3156251

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000943	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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