Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1459)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0770909	0.0998212	0.4485477
Weighted median	23	0.0181899	0.0557638	0.7442765
Inverse variance weighted	23	-0.0400221	0.0390156	0.3049871
Simple mode	23	0.0067966	0.0908095	0.9410146
Weighted mode	23	0.0182791	0.0616404	0.7695960

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.67615	21	0.7875620
Inverse variance weighted	17.30081	22	0.7465456

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071919	0.0056424	0.2163674

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005561	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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