Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1458)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0708528	0.1026384	0.4975559
Weighted median	23	0.0220441	0.0578450	0.7031368
Inverse variance weighted	23	0.0307636	0.0393623	0.4344789
Simple mode	23	-0.0839518	0.1021005	0.4197593
Weighted mode	23	-0.0161226	0.0816867	0.8453493

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.20259	21	0.3879169
Inverse variance weighted	22.39297	22	0.4366532

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024619	0.0058016	0.6756322

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006974	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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