Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1457)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0308698	0.1079952	0.7777979
Weighted median	23	-0.0473391	0.0546722	0.3865609
Inverse variance weighted	23	-0.0013156	0.0413270	0.9746054
Simple mode	23	-0.0482852	0.0942372	0.6134916
Weighted mode	23	-0.0482852	0.0619108	0.4437511

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.58031	21	0.2657985
Inverse variance weighted	24.68377	22	0.3124348

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018149	0.0061044	0.7691481

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000748	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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