Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1456)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0390694	0.1424631	0.7865783
Weighted median	23	-0.0121768	0.0552523	0.8255716
Inverse variance weighted	23	-0.0473528	0.0549622	0.3889348
Simple mode	23	-0.0110010	0.0742638	0.8835862
Weighted mode	23	-0.0071389	0.0557979	0.8993574

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.77484	21	0.0033580
Inverse variance weighted	43.65957	22	0.0039107

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053071	0.0080526	0.5170228

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013674	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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