Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1455)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1712426	0.1108409	0.1372977
Weighted median	23	0.0446167	0.0591963	0.4510248
Inverse variance weighted	23	0.0137771	0.0446632	0.7577270
Simple mode	23	0.0658261	0.1008639	0.5207615
Weighted mode	23	0.0576537	0.0715696	0.4291171

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.89327	21	0.2105479
Inverse variance weighted	28.83050	22	0.1497642

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0096699	0.0062653	0.1376645

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008774	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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