Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1454)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0996435	0.1212568	0.4204480
Weighted median	23	0.0886293	0.0548599	0.1061900
Inverse variance weighted	23	0.0400058	0.0466181	0.3908041
Simple mode	23	0.0581668	0.0892247	0.5212103
Weighted mode	23	0.0715084	0.0616043	0.2581762

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.98808	21	0.0738566
Inverse variance weighted	31.40939	22	0.0880377

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036623	0.006854	0.5987213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009836	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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