Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1453)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0874500	0.0998206	0.3909025
Weighted median	23	0.0297376	0.0536292	0.5792338
Inverse variance weighted	23	0.0376313	0.0390158	0.3347875
Simple mode	23	0.0237508	0.0822607	0.7754943
Weighted mode	23	0.0178363	0.0637120	0.7821303

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.21782	21	0.9759429
Inverse variance weighted	10.51182	22	0.9810404

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030594	0.0056423	0.5933784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003467	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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