Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1452)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1860571	0.1276807	0.1598513
Weighted median	23	-0.0818178	0.0564972	0.1475684
Inverse variance weighted	23	-0.0150896	0.0511550	0.7680108
Simple mode	23	-0.0466729	0.1005630	0.6471246
Weighted mode	23	-0.0616665	0.0596150	0.3121813

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.35837	21	0.0331625
Inverse variance weighted	37.82086	22	0.0191880

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0104991	0.0072171	0.1605249

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011505	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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