Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1451)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0555237	0.1272349	0.6670094
Weighted median	23	-0.0026921	0.0571577	0.9624344
Inverse variance weighted	23	-0.0224169	0.0486796	0.6451589
Simple mode	23	-0.0512340	0.1040024	0.6271594
Weighted mode	23	-0.0104574	0.0604959	0.8643410

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.11908	21	0.0351897
Inverse variance weighted	34.24892	22	0.0463341

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020331	0.0071919	0.7801821

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010478	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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