Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1450)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0027812	0.0998205	0.9780351
Weighted median	23	-0.0327956	0.0555011	0.5545874
Inverse variance weighted	23	-0.0437720	0.0390156	0.2619011
Simple mode	23	-0.1155890	0.0932558	0.2282267
Weighted mode	23	-0.0045540	0.0720981	0.9502059

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.83255	21	0.7212057
Inverse variance weighted	17.08927	22	0.7584158

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028588	0.0056423	0.617662

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000556	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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