Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 145)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0386413	0.0998194	0.7025687
Weighted median	23	-0.0688008	0.0561871	0.2207657
Inverse variance weighted	23	-0.0271835	0.0390154	0.4859663
Simple mode	23	0.0966187	0.1083794	0.3823159
Weighted mode	23	-0.1172800	0.0783072	0.1484250

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.75585	21	0.6007987
Inverse variance weighted	18.77140	22	0.6593990

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007036	0.0056423	0.9019433

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005835	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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