Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1449)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0242971	0.0998202	0.8100512
Weighted median	23	-0.0097284	0.0569038	0.8642539
Inverse variance weighted	23	0.0084019	0.0390155	0.8294971
Simple mode	23	0.0592708	0.0957191	0.5421340
Weighted mode	23	-0.0583408	0.0780458	0.4626652

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.54457	21	0.6143300
Inverse variance weighted	18.67123	22	0.6655329

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002008	0.0056423	0.7254743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005672	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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