Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1448)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1156610	0.0998204	0.2595891
Weighted median	23	0.0927050	0.0563219	0.0997668
Inverse variance weighted	23	0.0407284	0.0390154	0.2965296
Simple mode	23	0.1509175	0.0875900	0.0989177
Weighted mode	23	0.1248172	0.0702943	0.0896289

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.93134	21	0.5895449
Inverse variance weighted	19.59646	22	0.6082660

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046016	0.0056423	0.4239113

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006269	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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