Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1447)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0851312	0.0998197	0.4033653
Weighted median	23	0.0012103	0.0573724	0.9831691
Inverse variance weighted	23	-0.0318202	0.0390154	0.4147397
Simple mode	23	-0.0069814	0.1137822	0.9516281
Weighted mode	23	0.0185615	0.0723436	0.7998911

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.89805	21	0.5916798
Inverse variance weighted	19.23472	22	0.6307930

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032738	0.0056423	0.5679341

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000603	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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