Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1446)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0316551	0.0998212	0.7542855
Weighted median	23	-0.0175694	0.0549491	0.7491656
Inverse variance weighted	23	-0.0380773	0.0390155	0.3290874
Simple mode	23	0.0462080	0.0828108	0.5824823
Weighted mode	23	-0.0072764	0.0624781	0.9083426

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.48345	21	0.490851
Inverse variance weighted	20.48833	22	0.552522

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003944	0.0056424	0.9449361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006497	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8