Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1445)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0251144	0.1162011	0.8309726
Weighted median	23	0.0258533	0.0610219	0.6718042
Inverse variance weighted	23	0.0245914	0.0446020	0.5813930
Simple mode	23	0.0488288	0.1101072	0.6617592
Weighted mode	23	0.0528193	0.0819322	0.5258068

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.45900	21	0.1276072
Inverse variance weighted	28.75168	22	0.1520879

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030525	0.0065683	0.6469097

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008833	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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