Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1444)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1318586	0.0998192	0.2007245
Weighted median	23	0.0220184	0.0600741	0.7139760
Inverse variance weighted	23	0.0455970	0.0390152	0.2425256
Simple mode	23	0.0071255	0.1060291	0.9470270
Weighted mode	23	0.0009170	0.0785887	0.9907949

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.58649	21	0.5475713
Inverse variance weighted	20.46796	22	0.5537930

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052973	0.0056423	0.3584746

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006616	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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