Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1443)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0161870	0.0998206	0.8727297
Weighted median	23	0.0233671	0.0526333	0.6570716
Inverse variance weighted	23	0.0278030	0.0390158	0.4760877
Simple mode	23	0.0396975	0.0725499	0.5897662
Weighted mode	23	0.0283731	0.0577245	0.6279222

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.82536	21	0.4696529
Inverse variance weighted	20.84135	22	0.5305610

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007133	0.0056423	0.9005973

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006468	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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