Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1442)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0211590	0.0999682	0.8344152
Weighted median	23	-0.0274956	0.0567567	0.6280684
Inverse variance weighted	23	0.0351771	0.0390155	0.3672600
Simple mode	23	0.1181498	0.1038760	0.2676030
Weighted mode	23	0.0149175	0.0698816	0.8329274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.06208	21	0.4551584
Inverse variance weighted	21.43803	22	0.4938265

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034596	0.0056507	0.54695

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006743	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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