Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1441)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0811502	0.1199199	0.5059803
Weighted median	23	0.0237280	0.0541357	0.6611640
Inverse variance weighted	23	-0.0090000	0.0462575	0.8457354
Simple mode	23	-0.0019368	0.0884837	0.9827338
Weighted mode	23	-0.0052712	0.0633917	0.9344817

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.30838	21	0.0859641
Inverse variance weighted	30.92503	22	0.0976599

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044307	0.0067784	0.5204307

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009387	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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