Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1440)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1477440	0.0998209	0.1536963
Weighted median	23	-0.0262176	0.0554603	0.6364080
Inverse variance weighted	23	-0.0407497	0.0390156	0.2962789
Simple mode	23	0.0411068	0.0899853	0.6522811
Weighted mode	23	-0.0108841	0.0630078	0.8644332

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.43566	21	0.4938360
Inverse variance weighted	21.79171	22	0.4723786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065705	0.0056424	0.2572823

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006934	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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