Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 144)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0762066	0.0998206	0.4536956
Weighted median	23	0.0196346	0.0562772	0.7271712
Inverse variance weighted	23	0.0057898	0.0390157	0.8820294
Simple mode	23	-0.1509147	0.0993894	0.1431494
Weighted mode	23	0.0312335	0.0668191	0.6447868

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.02776	21	0.5833590
Inverse variance weighted	19.61513	22	0.6071002

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043243	0.0056424	0.4519682

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005951	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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