Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1439)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0073853	0.0998206	0.9417216
Weighted median	23	0.0020303	0.0522274	0.9689904
Inverse variance weighted	23	0.0044040	0.0390157	0.9101268
Simple mode	23	-0.0126893	0.0791569	0.8741034
Weighted mode	23	-0.0157869	0.0593094	0.7925802

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.29353	21	0.6931664
Inverse variance weighted	17.31000	22	0.7460254

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000724	0.0056423	0.8991223

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005249	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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