Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1438)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0361651	0.1157964	0.7578805
Weighted median	23	-0.0318970	0.0592562	0.5903778
Inverse variance weighted	23	-0.0271215	0.0445887	0.5430160
Simple mode	23	-0.2208229	0.1079515	0.0529384
Weighted mode	23	-0.0405988	0.0606287	0.5100612

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.25984	21	0.1329347
Inverse variance weighted	28.73428	22	0.1526049

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038864	0.0065453	0.559011

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008854	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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