Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1437)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0057091	0.0998207	0.9549319
Weighted median	23	0.0585835	0.0570221	0.3042407
Inverse variance weighted	23	0.0126395	0.0390156	0.7459676
Simple mode	23	0.0983127	0.0911219	0.2923135
Weighted mode	23	0.0704060	0.0677589	0.3100600

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.87599	21	0.5930949
Inverse variance weighted	18.88168	22	0.6526229

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004256	0.0056424	0.9405871

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005754	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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