Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1436)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0094437	0.1019078	0.9270449
Weighted median	23	-0.0102495	0.0526088	0.8455299
Inverse variance weighted	23	-0.0043599	0.0390156	0.9110236
Simple mode	23	-0.0565175	0.0879217	0.5269868
Weighted mode	23	-0.0167454	0.0611870	0.7868867

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.88751	21	0.4060171
Inverse variance weighted	21.91008	22	0.4652668

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008477	0.0057603	0.8844109

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006643	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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