Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1435)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1047556	0.0998203	0.3059031
Weighted median	23	0.0381465	0.0570930	0.5040395
Inverse variance weighted	23	0.0078458	0.0390156	0.8406243
Simple mode	23	-0.0098678	0.1034323	0.9248582
Weighted mode	23	0.0041994	0.0809448	0.9590929

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.85635	21	0.9135721
Inverse variance weighted	13.96884	22	0.9025815

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059512	0.0056423	0.3035262

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004245	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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