Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1434)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0143708	0.1212733	0.9067983
Weighted median	23	0.0292101	0.0598851	0.6257140
Inverse variance weighted	23	0.0270407	0.0463252	0.5594116
Simple mode	23	-0.0769259	0.1034074	0.4648021
Weighted mode	23	-0.0119591	0.0800215	0.8825610

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.99712	21	0.0737058
Inverse variance weighted	31.01614	22	0.0957857

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007781	0.006855	0.9107096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009544	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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