Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1433)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1436833	0.0998204	0.1647726
Weighted median	23	0.0325264	0.0568027	0.5669022
Inverse variance weighted	23	0.0457682	0.0409161	0.2633164
Simple mode	23	0.0601349	0.0901940	0.5118778
Weighted mode	23	0.0288813	0.0644273	0.6583370

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.94390	21	0.5248174
Inverse variance weighted	24.19554	22	0.3370639

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0116342	0.0056423	0.0518038

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007749	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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