Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1432)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0285940	0.1099405	0.7973300
Weighted median	23	0.0037794	0.0568946	0.9470371
Inverse variance weighted	23	0.0117025	0.0420107	0.7805832
Simple mode	23	0.0280524	0.0973601	0.7759440
Weighted mode	23	-0.0025262	0.0656843	0.9696681

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.47372	21	0.2272301
Inverse variance weighted	25.50752	22	0.2734257

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010373	0.0062144	0.8690289

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007757	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8