Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1431)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1199557	0.0998209	0.2428533
Weighted median	23	-0.0541186	0.0558797	0.3328026
Inverse variance weighted	23	-0.0472033	0.0390158	0.2263367
Simple mode	23	-0.0720082	0.0865430	0.4143210
Weighted mode	23	-0.0595258	0.0715250	0.4142183

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.62104	21	0.9492881
Inverse variance weighted	12.24802	22	0.9520433

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044677	0.0056424	0.4373197

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004155	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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