Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1430)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0534994	0.0998203	0.5976203
Weighted median	23	0.0245832	0.0560338	0.6608632
Inverse variance weighted	23	-0.0011124	0.0390156	0.9772530
Simple mode	23	0.0685181	0.0976727	0.4903417
Weighted mode	23	0.0736091	0.0676284	0.2881834

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.09211	21	0.7644537
Inverse variance weighted	16.44540	22	0.7931826

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033537	0.0056423	0.5586054

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004984	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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