Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 143)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1326269	0.1123811	0.2511354
Weighted median	23	-0.0279509	0.0585978	0.6333654
Inverse variance weighted	23	0.0092144	0.0443457	0.8353966
Simple mode	23	0.0702393	0.1068890	0.5179172
Weighted mode	23	-0.0058903	0.0838833	0.9446532

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.61793	21	0.1838604
Inverse variance weighted	28.42213	22	0.1621100

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075788	0.0063523	0.2461484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008629	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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