Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1429)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0100122	0.1129349	0.9301968
Weighted median	23	0.0484654	0.0564986	0.3909947
Inverse variance weighted	23	-0.0160936	0.0431298	0.7090419
Simple mode	23	0.0787408	0.0888865	0.3852750
Weighted mode	23	0.0598453	0.0616600	0.3423134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.88034	21	0.1748491
Inverse variance weighted	26.88472	22	0.2156376

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003735	0.0063836	0.9539013

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008198	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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