Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1428)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3052296	0.0998186	0.0059752
Weighted median	23	0.1412072	0.0594123	0.0174668
Inverse variance weighted	23	0.0726545	0.0390149	0.0625717
Simple mode	23	0.1268269	0.1102082	0.2621721
Weighted mode	23	0.1533685	0.0770922	0.0592298

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.76337	21	0.8795474
Inverse variance weighted	20.17107	22	0.5723397

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0142826	0.0056423	0.0194149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007163	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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