Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1427)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1004167	0.1351451	0.4656958
Weighted median	23	-0.0615327	0.0590969	0.2977748
Inverse variance weighted	23	-0.0066485	0.0525102	0.8992459
Simple mode	23	-0.1113225	0.1031847	0.2923340
Weighted mode	23	-0.0588721	0.0626286	0.3574146

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.49326	21	0.0112755
Inverse variance weighted	39.85114	22	0.0112528

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065749	0.007639	0.3991287

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012084	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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