Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1426)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0937093	0.1140094	0.4203441
Weighted median	23	0.0150104	0.0629601	0.8115617
Inverse variance weighted	23	0.0319148	0.0438949	0.4671813
Simple mode	23	-0.0903746	0.1297830	0.4935005
Weighted mode	23	-0.0068096	0.0937686	0.9427639

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.39486	21	0.1581626
Inverse variance weighted	27.84720	22	0.1808007

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037948	0.0064444	0.5622402

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008641	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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