Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1425)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0358134	0.1143210	0.7571653
Weighted median	23	0.0001995	0.0543917	0.9970733
Inverse variance weighted	23	-0.0227777	0.0436719	0.6019741
Simple mode	23	0.0080786	0.0825340	0.9229123
Weighted mode	23	-0.0026587	0.0567199	0.9630361

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.54419	21	0.1535582
Inverse variance weighted	27.56432	22	0.1905727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008005	0.0064619	0.9025867

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008456	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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