Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1424)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1534255	0.0998207	0.1392220
Weighted median	23	-0.0498161	0.0572890	0.3845415
Inverse variance weighted	23	-0.0273529	0.0390156	0.4832550
Simple mode	23	-0.0667411	0.0961058	0.4946664
Weighted mode	23	-0.0468058	0.0718038	0.5212455

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.22479	21	0.8597512
Inverse variance weighted	16.10757	22	0.8105116

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077421	0.0056424	0.1844998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000503	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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