Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1423)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0052637	0.1033142	0.9598480
Weighted median	23	0.0136884	0.0545184	0.8017526
Inverse variance weighted	23	0.0094619	0.0394546	0.8104706
Simple mode	23	-0.0133403	0.0860196	0.8781690
Weighted mode	23	0.0108647	0.0564781	0.8492168

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.49544	21	0.3714584
Inverse variance weighted	22.49752	22	0.4305498

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002578	0.0058398	0.9652039

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006835	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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