Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1422)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1466945	0.1053926	0.1785244
Weighted median	23	0.0007144	0.0619674	0.9908015
Inverse variance weighted	23	0.0009100	0.0423553	0.9828590
Simple mode	23	-0.0400998	0.1037652	0.7028780
Weighted mode	23	-0.0142957	0.0881137	0.8725963

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.41053	21	0.3224862
Inverse variance weighted	25.92817	22	0.2547787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089526	0.0059573	0.1477807

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8