Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1421)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0821523	0.1111355	0.4679631
Weighted median	23	-0.0237703	0.0562883	0.6728094
Inverse variance weighted	23	-0.0353076	0.0437518	0.4196682
Simple mode	23	0.0089730	0.0977101	0.9276619
Weighted mode	23	-0.0167926	0.0617008	0.7880357

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.03114	21	0.2052642
Inverse variance weighted	27.66550	22	0.1870332

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072132	0.0062819	0.2637772

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008631	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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