Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1420)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0102365	0.1176307	0.9314779
Weighted median	23	0.0246205	0.0607356	0.6852038
Inverse variance weighted	23	0.0056377	0.0449426	0.9001738
Simple mode	23	-0.0649645	0.1074828	0.5517493
Weighted mode	23	0.0075044	0.0701406	0.9157655

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.16225	21	0.1101603
Inverse variance weighted	29.19210	22	0.1394575

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009748	0.0066491	0.8848363

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008852	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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