Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 142)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1229928	0.0998200	0.2315130
Weighted median	23	-0.0131240	0.0581496	0.8214400
Inverse variance weighted	23	-0.0035220	0.0394645	0.9288867
Simple mode	23	0.0271174	0.0922187	0.7714724
Weighted mode	23	0.0085566	0.0687674	0.9021068

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.81816	21	0.4700963
Inverse variance weighted	22.50894	22	0.4298853

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073367	0.0056423	0.2075882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006823	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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