Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1419)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0467165	0.1168503	0.6933428
Weighted median	23	0.0648508	0.0553551	0.2413811
Inverse variance weighted	23	0.0263495	0.0451095	0.5591378
Simple mode	23	0.0387846	0.0899955	0.6706896
Weighted mode	23	0.0429318	0.0647815	0.5143958

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.77669	21	0.1194669
Inverse variance weighted	29.40909	22	0.1335478

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004487	0.0066049	0.5043446

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000905	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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